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At the meantime, incorporation of brain targeting motifs allows nanogel transcytosis across the BBB for brain-targeted drug delivery

Also, extracellular GSH molecule is not transported into cells, but is cleaved into its component amino acids by gamma-glutamyl transpeptidase (GGT) and aminopeptidases

MTX also inhibits the bifunctional purine biosynthesis protein PURH (ATIC), blocking the conversion of the aminoimidazole carboxamide ribonucleotide (AICAR) into inosine monophosphate (IMP), thus inhibiting purine synthesis and the production of adenosine